解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050912z
更新日期:2006-05-01 00:00:00
abstract::A cellulose-chitin hybrid polysaccharide having alternatingly beta(1-->4)-linked D-glucose (Glc) and N-acetyl-d-glucosamine (GlcNAc) was synthesized via two modes of enzymatic polymerization. First, a sugar oxazoline monomer of Glcbeta(1-->4)GlcNAc (1) was designed as a transition-state analogue substrate (TSAS) monom...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060094q
更新日期:2006-05-01 00:00:00
abstract::As an aim toward developing biologically mimetic and functional nanofiber-based tissue engineering scaffolds, we demonstrated the encapsulation of a model protein, fluorescein isothiocyanate-conjugated bovine serum albumin (fitcBSA), along with a water-soluble polymer, poly(ethylene glycol) (PEG), within the biodegrad...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050743i
更新日期:2006-04-01 00:00:00
abstract::Chitosan is a well sought-after polysaccharide in biomedical applications and has been blended with various macromolecules to mitigate undesirable properties. However, the effects of blending on the unique antibacterial activity of chitosan as well as changes in fatigue and degradation properties are not well understo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050935d
更新日期:2006-04-01 00:00:00
abstract::Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0600522
更新日期:2006-04-01 00:00:00
abstract::Electrically conducting polymeric membranes were prepared by incorporating multiwalled carbon nanotubes (MWCNTs) into bacterial cellulose pellicles produced by Gluconacetobacter xylinum. The MWCNTs were dispersed in a surfactant (cationic cetyl trimethylammonium bromide) solution, and cellulose pellicles were dipped i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050597g
更新日期:2006-04-01 00:00:00
abstract::Human serum albumin (HSA) is known to exist as N (pH approximately 7), B (pH approximately 9), and F (pH approximately 3.5) isomeric forms and an equilibrium intermediate state (I) accumulate in the urea induced unfolding pathway of HSA around 4.8-5.2 M urea concentrations. These states displayed characteristic struct...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050996b
更新日期:2006-04-01 00:00:00
abstract::The electrospinning of polymer melts can offer an advantage over solution electrospinning, in the development of layered tissue constructs for tissue engineering. Melt electrospinning does not require a solvent, of which many are cytotoxic in nature, and the use of nonwater soluble polymers allows the collection of fi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050777q
更新日期:2006-03-01 00:00:00
abstract::A scanning laser system has been used to generate three-dimensional trimethylolpropane trimethacrylate (TRIM) cross-linked poly(2-hydroxylethyl methacrylate) polymer microstructures through azo-bis(isobutyro)nitrile (AIBN) photopolymerization using a 20 x 0.5 NA microscope objective and 365 nm laser excitation. Macrop...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0506952
更新日期:2006-03-01 00:00:00
abstract::The objective of these investigations was to test the hypothesis that a rapid cytoplasmic release profile from nanoparticles would potentiate the anticancer activity of cisplatin. Cisplatin-loaded nanoparticles with pH-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEA) cores were synthesized from PDEA-bloc...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050902y
更新日期:2006-03-01 00:00:00
abstract::A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0507094
更新日期:2006-03-01 00:00:00
abstract::The mechanical and melt flow properties of two thermoplastic potato starch materials with different amylose contents were evaluated. The materials were prepared by mixing starch, glycerol, and water, mainly in the weight proportions of 10:3:4.5. Compression molding was used to produce sheets/films with a thickness in ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050804c
更新日期:2006-03-01 00:00:00
abstract::Electrospinning is a versatile process used to prepare micro- and nano- sized fibers from various polymers dissolved in volatile solvents. In this report, cellulose and cellulose-heparin composite fibers are prepared from nonvolatile room temperature ionic liquid (RTIL) solvents by electrospinning. RTILs are extracted...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050837s
更新日期:2006-02-01 00:00:00
abstract::A variety of important biological events are mediated by the multivalent interaction between relevant oligosaccharides and multiple saccharide receptors on lectins, toxins, and cell surfaces; a variety of glycopolymeric materials have therefore been investigated in studies aimed at manipulating these events. The synth...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050672n
更新日期:2006-02-01 00:00:00
abstract::Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050601o
更新日期:2006-02-01 00:00:00
abstract::The calcium-binding sites of calbindin D(9k) have a helix-loop-helix motif. In this study, the helix motifs were replaced by several Ala-Gly repeating regions designed on the basis of the primary sequences of several silk fibroins. The synthesized peptides were treated with several organic solvents to modify the secon...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050863q
更新日期:2006-02-01 00:00:00
abstract::Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0505078
更新日期:2006-01-01 00:00:00
abstract::Structures of three pectic arabinogalactans, one from Vernonia kotschyana (Vk2a) and two from Cochlospermum tinctorium (Ct50A1 and Ct50A2), and their complement fixation and induction of B cell proliferation in vitro were compared. The polysaccharide Vk2a expressed potent biological activity in both assays compared wi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050355g
更新日期:2006-01-01 00:00:00
abstract::Many dental restorative dental composites still utilize 2,2-bis[4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane (Bis-GMA) as base resin. The high viscosity of Bis-GMA necessitates dilution with dimethacrylate ethers of low viscosity such as triethylene glycol dimethacrylate (TEGDMA). However, increased amounts...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050491l
更新日期:2006-01-01 00:00:00
abstract::Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0506086
更新日期:2006-01-01 00:00:00
abstract::Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050663e
更新日期:2006-01-01 00:00:00
abstract::Surface pressure isotherms and structural and surface dilatational properties of three hydroxypropylmethycelluloses (HPMCs, called E4M, E50LV, and F4M) adsorbed films at the air-water interface were determined. In this work we present evidence that HPMC molecules are able to diffuse and saturate the air-water interfac...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050757o
更新日期:2006-01-01 00:00:00
abstract::A novel pH and temperature sensitive block copolymer was prepared by adding pH sensitive moiety to temperature sensitive block copolymer. This block copolymer solution showed a reversible sol-gel transition by a small pH change in the range of pH 7.4-8.0 and also by the temperature change in the region of body tempera...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050521k
更新日期:2005-11-01 00:00:00
abstract::F-actins are semi-flexible polyelectrolytes and can be assembled into a large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase behavior and the growth of polymer-actin complexes in terms of its longitudinal and lateral sizes in var...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050320g
更新日期:2005-11-01 00:00:00
abstract::Mixed protein-based hydrogels have been prepared by blending gelatin (G) with amorphous Bombyx mori silk fibroin (SF) and promoting beta-crystallization of SF via subsequent exposure to methanol or methanol/water solutions. The introduction of beta crystals in SF serves to stabilize the hydrogel network and extend the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050396c
更新日期:2005-11-01 00:00:00
abstract::Major ampullate silk, also known as dragline silk, is one of the strongest biomaterials known. This silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2). Only partial cDNA sequences have been obtained for these proteins, and these sequences are toward the C-termin...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050472b
更新日期:2005-11-01 00:00:00
abstract::New aspects concerning the mechanism of formation of chitosan physical hydrogels without any cross-linking agent were studied. The gelation took place during the evaporation of a hydroalcoholic solution of chitosan. We first demonstrated that it was possible to form a physical hydrogel from a hydrochloride form of chi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050653d
更新日期:2005-11-01 00:00:00
abstract::N-(3-Aminopropyl)pyrrole was covalently coupled with alginate in an aqueous-phase reaction by means of carbodiimide-mediated activation chemistry to provide a pyrrole-alginate conjugate for subsequent use in biosensor applications. The pyrrole-alginate conjugate was quantified by UV spectroscopy at 230 nm, by an HPSEC...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050339j
更新日期:2005-11-01 00:00:00
abstract::New applications in regenerative biotechnology require the ability to understand and control protein-surface interactions on micrometer and submicrometer length scales. Evidence presented here shows that micropatterned amphiphilic comb polymer films exhibit a pretreatment-dependent behavior with respect to protein ads...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050446d
更新日期:2005-11-01 00:00:00
abstract::Lignin-carbohydrate complexes (LCCs) were prepared in quantitative yield from spruce wood and from the corresponding kraft and oxygen-delignified pulps and were separated into different fractions on the basis of their carbohydrate composition. To obtain an understanding of the differences in lignin structure and react...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm058014q
更新日期:2005-11-01 00:00:00
abstract::This work reports on the effect of CO2 at subcritical conditions and the gaseous state on the telechelic poly(epsilon-caprolactone) polymers. The tested polymers are semi-crystalline in nature and thus the effect of functional groups and their overall contribution to foaming and formation of microstructures with open-...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050223n
更新日期:2005-09-01 00:00:00
abstract::A novel strategy for artificial regulation system of gene expression applying the specific molecular recognition between carbohydrate and lectin is proposed. Plasmid-lactose conjugates (pActin-lactose and pGFP-lactose) prepared via diazocoupling maintained the transcription activity with T7 RNA polymerase. Gel-shift a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050255a
更新日期:2005-09-01 00:00:00
abstract::On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0502011
更新日期:2005-09-01 00:00:00
abstract::Polymeric prodrugs of mPEG-PLA-haloperidol (methoxypoly(ethylene glycol)-b-poly(lactic acid)) can self-assemble into nanoscale micelle-like structures in aqueous solutions. mPEG-PLA-haloperidol was prepared and characterized using 1H and 13C NMR. The conjugation efficiency was found to be 64.8 +/- 21%. Micelles that f...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050188k
更新日期:2005-09-01 00:00:00
abstract::Oligosaccharides of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and methyl cellulose were investigated by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The cellulose ether oligosaccharides were produced either by enzymatic depolymerization utilizing the purified family 5 endoglu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050270f
更新日期:2005-09-01 00:00:00
abstract::A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytotoxicity. The poly(vinyl alcohol) derivatives were prepared by partial...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0504328
更新日期:2005-09-01 00:00:00
abstract::Deproteinized natural rubber latex (DPNR-latex) was treated with lipase and phosphatase in order to analyze the structure of the chain-end group (alpha-terminal). The enzymatic treatment decreased the content of long-chain fatty acid ester groups in DPNR from about 6 to 2 mol per rubber molecule. The molecular weight ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm058003x
更新日期:2005-07-01 00:00:00
abstract::Binding interactions between low molecular weight heparin (LMWH) and heparin-binding peptides (HBP) have been applied as a strategy for the assembly of hydrogels that are capable of sequestering growth factors and delivering them in a controlled manner. In this work, the assembly of four-arm star poly(ethylene glycol)...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0500042
更新日期:2005-07-01 00:00:00
abstract::Electrospinning is a simple and versatile technique of producing polymeric fibers ranging from submicron to micron in diameter. Incorporation of bioactive agents into the fibers could make a biofunctional tissue engineering scaffold. In this study, we investigated the feasibility of encapsulating human beta-nerve grow...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0501149
更新日期:2005-07-01 00:00:00
abstract::Functionally designed elastomeric nanofiber fabrics made of the equimolar copolyester, poly(L-lactide-co-epsilon-caprolactone) (PLCL), with type I collagen or the tri-n-butylamine salt of heparin (heparin-TBA) were co-electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. The co-electrospun fabrics (...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050086u
更新日期:2005-07-01 00:00:00